CASP3 and neoplasm: We also assessed the effects of MPT0B291 (25 mg/kg, p.o.) on tumor cell proliferation (by Ki67 staining) and apoptosis (by cleaved caspase-3 staining) in sham (without tumor) and U-87MG xenografted mice, More Ki67-possitive cells were observed in brain sections from U-87MG xenografted mice than those from sham mice.