AKT1 and myocardial infarction: Our previous study has shown that MAPK and Akt signaling markedly upregulated in acute myocardial infarction in porcine that was suppressed by tacrolimus treatment.37 Interestingly, in the in vivo studies, we also found that the PI3K/p-AKT/m-TOR signaling pathway was markedly upregulated in F344HS animals than in SC counterparts, suggesting an intrinsic response to ischemic stimulation.