In diabetic renal fibrosis mouse model, CK2α expression was increased in the kidney and treatment of TBB (a selective inhibitor of CK2) or CK2α RNAi adenovirus infection to the mice reduced renal fibrosis by suppressing IκB degradation and NF-κB nuclear accumulation 18.Our study proved that TH1 cells treated with P-cresol showed increased expression of CK2α, and the knockdown of CK2α decreased the expression of Pfn1. This evidence concerns the gene PFN1 and renal fibrosis.