In addition, in agreement with the advances of serum IgA autoantibodies for the diagnosis of some malignancies 8-9, we also performed the screening of serum IgA autoantibody biomarkers by HuProt array and found some IgA autoantibodies with good diagnostic value for early lung cancer, of which IgA antibody against TIF1γ was demonstrated the optimal diagnostic performance for the patients with lung cancer at early stage by validation of ELISA assay 10. The gene discussed is TRIM33; the disease is lung cancer.