Combined with the results above that IKKα induced thyroid cancer cell differentiation separable from its activation on NF-κB signaling and CRSP8 dedifferentiated thyroid cancer cells via its downregulation on IKKα expression, these data implied that although CRSP8 could activate NF-κB, CRSP8 dedifferentiated thyroid cancer cell through IKKα signaling bypass NF-κB. The gene discussed is MED27; the disease is thyroid gland carcinoma.