Here, total active corticosterone and inactive 11-DHC, increased in TNF-tg and TNF‐tg11βKO mice, with the reduced transcortin binding affinity of 11-DC predicted to further elevate its circulating free levels.25 In the models of polyarthritis, disease activity, synovitis and joint destruction were markedly suppressed in animals receiving corticosterone. This evidence concerns the gene SERPINA6 and synovitis.