SDHA and Leigh syndrome: The first affected child presented at 4 years of age with encephalopathy and developmental regression following viral illnesses; MRI changes supported a clinical diagnosis of Leigh syndrome and bi-allelic c.117del p.(Asn40Thrfs*18) and c.221dup p.(Leu74Phefs*9) SDHA variants were identified (Case 9,Table 1) [25].