SDHAF1 and Dysarthria: Firstly, two siblings presented at 11 and 12 months of age with dysarthria, dysphonia and dysphagia precipitated by injury or fever; they were subsequently found to each harbour a homozygous c.3G>A SDHAF1 variant which is predicted to abolish the initiation methionine residue and therefore the translation of SDHAF1 (Cases 58 and 59, Table 1) [26].