Notable differences between the XPRES cohorts and TBFT external validation cohort were that the TBFT cohort had a higher prevalence of markers of advanced disease, with a higher prevalence of ≥ 1 TB symptom (79% versus 30%), lower median CD4 count (72 versus 240–245/μL), and higher incidence of all-cause 6-month ART mortality (6.0% versus 2.5–2.9%) (Table 1). Here, CD4 is linked to tuberculosis.