High expression of NOP10 protein whether in the nucleus or in the nucleoli showed a significant association with aggressive characteristics including; higher tumour grade (p < 0.0001), poor NPI (p = 0.006 & p = 0.002), higher mitotic scores (p = 0.0003 & p = 0.0002), higher nuclear pleomorphism (p < 0.0001 & p = 0.017) and higher nucleolar score (p = 0.003 & p < 0.0001). Here, NOP10 is linked to neoplasm.