The high level of rRNA methylation resulted in initiating protein translation through a process called internal ribosome entry sequences (IRESs) which resulted in products that promote tumour development (The insulin-like growth factor 1 (IGF-1R), c-Myc, Vascular endothelial growth factor A (VEGF-A) and acidic fibroblast growth factor (FGF1)) [47–49]. The gene discussed is IGF1; the disease is neoplasm.