Based on previous studies, various HLA-A and HLA-DRB1 alleles have been shown to be associated with increased susceptibility to multiple autoimmune diseases, such as anti-LGI1 encephalitis, multiple sclerosis (MS), and rheumatoid arthritis (RA) [43, 44, 46–48]. The gene discussed is HLA-DRB1; the disease is encephalitis.