CDCA7 is cell division cycle associated protein-7 which is a c-MYC responsive gene and its role in c-MYC dependent tumourigenesis has been established by several studies [28, 29], while KIF4A is a member of kinesis family known to be a predictor and prognostic marker for hepatocellular carcinoma, oral and colorectal cancer [30–32]. The gene discussed is MYC; the disease is hepatocellular carcinoma.