Interestingly, some of the miR-17 downstream targets, such as SCN2B [52, 53], F2R [54], KCNB1 [55] and EGLN3 [56] that have been implicated in heart dysfunction, were down-regulated in the DCM hearts as revealed by expression analysis of linear RNAs, likely through the unleashed miR-17 that resulted from the down-regulation of circSCAF8_e4:TIAM2_e2 in DCM (Fig. 4e). Here, KCNB1 is linked to familial dilated cardiomyopathy.