Interestingly, 2 rt-circRNAs originating from SCAF8 and TIAM2, including SCAF8_e4:TIAM2_e1 and SCAF8_e4:TIAM2_e2, were remarkably downregulated in DCM (Fig. 3c). The gene discussed is SCAF8; the disease is familial dilated cardiomyopathy.