It is worth mentioning that the NF-κB-miR-146a signaling pathway, as a part of the innate immune system, appeared to be a proinflammatory factor involved in gut-brain communications, always acting as an Alzheimer's disease inducer (Lukiw 2004; Lukiw et al. 2010; McManus and Heneka 2017). Here, NFKB1 is linked to Alzheimer disease.