METTL3 and metabolic disease: To further investigate the underlying mechanisms of Mettl3-mediated m6A methylation in HFD-induced metabolic disorder, we performed RNA sequencing (RNA-seq) and m6A individual-nucleotide-resolution cross-linking and immunoprecipitation sequencing (miCLIP-seq) using mRNAs extracted from the livers of normal diet (ND) and HFD mice (Figure S1A).