Among them, Lpin1 has been reported to play an important role in liver lipid metabolism and insulin resistance [30], [31], [32], [33], Furthermore, Lpin1 protein decreased in Mettl3Ctrl(HFD) mouse liver (compared with Mettl3Ctrl(ND)) while increased in Mettl3cKO(HFD) mouse liver (compared with Mettl3Ctrl(HFD)). Here, LPIN1 is linked to Insulin resistance.