As EVD progressed, conventional CD14+ and CD16+ monocyte subsets largely disappeared and were replaced by two populations: CD14+ CD16+ (DP) monocytes, which increase in other infections (Michlmayr et al., 2018; Zanini et al., 2018a), and an unexpected CD14– CD16– (DN) population, that, to our knowledge, has not been previously described in viral infection. The gene discussed is FCGR3A; the disease is infection.