CCL2 and diabetic kidney disease: Several reports have shown that the activation of macrophage induction through the CCL2/CCR2 axis particularly induces injury to the nephron and renal tubes in CKDs, such as glomerulonephritis and diabetic kidney diseases (Wada et al. 2000; Tesch et al. 1999; Giunti et al. 2010; Tampe and Zeisberg 2014; Haller et al. 2016; Moreno et al. 2018).