In conclusion, the present findings suggest that the CCL2/CCR2 axis plays an important role in glomerulonephritis in CKD and that the QC/isoQC inhibitor PQ529 suppresses this axis by inhibiting the modification of glutamine with a pyroglutamate residue at the CCL2 N-terminal, consequently suppressing the inflammation in the kidney and exerting inhibitory effects on the progression of chronic renal failure in glomerulonephritis rats. The gene discussed is CCR2; the disease is glomerulonephritis.