The CCL2/CCR2 axis contributes to the mononuclear cell infiltration and inflammation in the kidney (Tesch et al. 1999; Giunti et al. 2010; Tampe and Zeisberg 2014; Haller et al. 2016; Moreno et al. 2018), and blockage of this axis exerts beneficial effects in experimental CKD models (Lloyd et al. 1997; Kitagawa et al. 2004; Kang et al. 2010; Sayyed et al. 2011) and human clinical CKD studies (de Zeeuw et al. 2015; Perez-Gomez et al. 2016; Menne et al. 2017). Here, CCR2 is linked to chronic kidney disease.