BRCA1 (OMIM#113705) and BRCA2 (OMIM#600185) germline pathogenic variants are associated with an increased risk for breast and ovarian cancers, while a smaller increase in cancer risk is observed for stomach, uterine, cervix, and colon cancer for BRCA1, and prostate, pancreatic, gallbladder, stomach cancer, and melanoma for BRCA2 (Palma et al., 2006). This evidence concerns the gene BRCA2 and malignant colon neoplasm.