BRCA1 and cancer: BRCA1 (OMIM#113705) and BRCA2 (OMIM#600185) germline pathogenic variants are associated with an increased risk for breast and ovarian cancers, while a smaller increase in cancer risk is observed for stomach, uterine, cervix, and colon cancer for BRCA1, and prostate, pancreatic, gallbladder, stomach cancer, and melanoma for BRCA2 (Palma et al., 2006).