KCTD12 and bipolar disorder: In addition, a GWAS in the Chinese population found that SNP rs2073831 in KCTD12, also within the shared homozygous region, was significantly associated with bipolar disorder (risk allele T global allele frequency 0.36).37 The homozygous 13q haplotype segregating in the family described includes the high-risk alleles for both of these SNPs, which may contribute to risk in the family.