SPRY2 and macroglossia: Linkage studies in multiplex families also provided evidence suggestive of linkage to this genomic region for both schizophrenia and bipolar disorder.38–40 Furthermore, a microdeletion encompassing the protein-coding genes RBM26, NDFIP2, and SPRY2 was identified in a fetus with macrocephaly and macroglossia, suggesting a role for these genes in brain development.41