At leukemia onset, it was observed an expansion of white blood cells (WBC) in Bcor−/−Dnmt3a−/− due to increased numbers of Gr1 + Mac1+ granulocytes, Gr1+Mac- monocytes and CD3 + lymphocytes together with a progressive expansion of a population of immature cells co-expressing c-Kit and the erythroid marker Ter119 (Fig. 3C). Here, KIT is linked to leukemia.