Resulting thrombocytosis derived from the accumulation of both megakaryocytic-erythroid (MEP, Lin−/Sca1−/Kit+CD34−FCyRII/IIIlo/−) and megakaryocytic progenitors (MkPs, Lin–c-Kit+Sca-1–CD150 + CD41+) (Fig. 1Bi–iii;) relied on a decrease of apoptosis (Fig. 1Biv) within BM cavity. The gene discussed is ITGA2B; the disease is Thrombocytosis.