CASP3 and metabolic dysfunction-associated steatohepatitis: Human NASH features strong p38α activation, which induces caspase 3 (CASP3) cleavage, AF4/FMR2 family member 4 (AFF4; also known as CHOP) expression, and BCL2 apoptosis regulator (BCL2) phosphorylation, thereby exacerbating hepatocyte death.