IFNG and Sepsis: For example, granulocyte–macrophage colony-stimulating factor (GM-CSF), interferon-gamma (IFN-γ), thymosin (Thymosin) and PD-1 antagonists have been proved to enhance immunity and reduce the occurrence and development of sepsis immunoparalysis but still have the defects of large side effects, high dosage, and short half-life5–8.