GDF15 and gestational diabetes: In regard to the contribution of biomolecules in the pathophysiology of GDM, this is not yet well known, however, recent studies have shown that the levels of Growth differentiation factor 15 (GDF15), also known as macrophage inhibitory cytokine-1 (MIC-1), are highly expressed the placenta, and this is identified as a pleiotropic protein that plays key roles in prenatal development, induced by both acute and chronic inflammatory states, acting directly on metabolism of carbohydrates and lipids of GDM women8,9.