MYC and acute myeloid leukemia: Incubation with R406 dose-dependently inhibited p-ERK1/2T202/Y204, p-STAT5Y694, and decreased MYC levels (Fig. 1C) in AML cells lines, and decreased p-ERK1/2T202/Y204 and p-STAT5Y694 in primary AML blasts (Fig. 1D).