Incubation with R406 dose-dependently inhibited p-ERK1/2T202/Y204, p-STAT5Y694, and decreased MYC levels (Fig. 1C) in AML cells lines, and decreased p-ERK1/2T202/Y204 and p-STAT5Y694 in primary AML blasts (Fig. 1D). The gene discussed is MAPK3; the disease is acute myeloid leukemia.