Strikingly, LRP1B was also associated with CIS in the human genetic association study and could represent a tag marker for two SNPs (not genotyped here) among the top 1.1–1.3% of deleterious variants in the human genome, according to CADD standards (rs62166498, 932 bp upstream, LD = 1, CADD = 15.66; rs62166499, 920 bp upstream, LD = 1, CADD = 17.85). The gene discussed is LRP1B; the disease is in situ carcinoma.