CD274 and cancer: Since PD-L1 glycosylation enhances PD-L1 protein stability13, epithelial-mesenchymal transition (EMT) triggers β-catenin-induced STT3 (N-glycosyltransferase) gene transcription and expression, resulting in PD-L1 glycosylation, which subsequently inhibits PD-L1 degradation in cancer stem cells23.