Palmitoyltransferase DHHC3 induces PD-L1 palmitoylation at cystine-272, inhibits its ubiquitination and endosomal sorting-mediated autophagic degradation, and subsequently enhances PD-L1 protein stability and immune suppression in a colon tumor model29. This evidence concerns the gene ZDHHC3 and colonic neoplasm.