On the one hand, in vitro studies have shown that BAMBI could promote skeletal muscle myogenic differentiation and transformation of myofiber type in C2C12 cells by activating Wnt/β-catenin signaling (9, 10), whereas in myocardium, BAMBI played a critical role in resisting cardiac hypertrophy by inhibiting TGF-β signaling (11). Here, BAMBI is linked to cardiac hypertrophy.