FGFR2 and cancer: Combined with the concomitant increased expression of the FGFR2-IIIC oncogenic isoform, deregulation of FGF signaling in PPB specimens might unbalance epithelial-mesenchymal homeostasis and stimulate cancer progression, as demonstrated in other cancers (Fig. 8; Oltean et al., 2006; Zhao et al., 2013; Ranieri et al., 2016).