PLOD1 and polycystic ovary syndrome: While extrapolation of findings from animal studies to human pathology should be done cautiously, our results in prenatal T-treated sheep, an animal model that recapitulates the neuroendocrine phenotype of PCOS, suggest that increased androgen signaling in the fetal pituitary combined with exacerbated insulin actions postnatally may underlie LH hypersecretion in PCOS.