In particular, CCR6 is known to mediate early recruitment of Th17 lymphocytes to CNS through its interaction with CCL20 (Chemokine Ligand 20) on choroid plexus and mice lacking CCR6 were shown to be highly resistant to the induction of EAE [21], and increasing evidence support a crucial role of Th17 in the pathogenesis of EAE and as auto-aggressive cells in MS [22–24]. Here, CCL20 is linked to myeloid sarcoma.