STXBP1 and Wolf-Hirschhorn syndrome: In this respect, bruxism and epilepsy in WHS might share a number of genetic abnormalities, as occurs in early infantile epileptic encephalopathy Type 4, which has been related to mutations in the STXBP1 gene, which participates in the pathway of neurotransmitters, including dopamine, and in which 80% of patients have diurnal bruxism [44].