Conceivably, depletion of periFN assembly by silencing endogenous FN expression did not affect tumor cell proliferation (Figure 6) as the actin SF cytoskeleton, which critically participates in cell proliferation [4,69,70], was not changed in shFN tumor cells (Figure 3) unless tumor cells were co-cultured with tumor cell-driven fibroblasts which subsequently activated tumor proliferation (Figure 7). Here, FN1 is linked to neoplasm.