AKT1 and neoplasm: In an animal cancer metastasis model, it has been shown that orally administered PS potently inhibited distant metastasis of suspended tumor cells in the circulation through suppressing cancerous periFN assembly due to AKT activation followed by ERK inactivation in an apoptosis-independent manner, whereas it drastically caused apoptosis of adherent tumor cells via AKT inactivation in solid tumor tissues [12].