However, as previously noted, CYP17A1 catalyzes 17α-hydroxylase and 17,20-lyase reactions, regulating the steroid hormones produced by the adrenal glands and gonads, thus individuals with clinically combined 17α-hydroxylase/17,20-lyase deficiency present with hypertension, hypokalemia, primary amenorrhea, and sexual infantilism. The gene discussed is CYP17A1; the disease is hyperinsulinemic hypoglycemia, familial, 4.