Indeed, Arnhold et al. [93] later published a study of seven sisters of patients with male Ps due to LH resistance and they concluded that women with LH resistance have spontaneous breast development, primary or secondary amenorrhoea, infertility, elevated serum LH levels and LH/FSH ratios with normal androgen levels, and normal or enlarged cystic ovaries. This evidence concerns the gene PLOD1 and Ovarian cyst.