IL6 and rheumatoid arthritis: As Scotece et al. (2012) described, in human chondrocytes, RA patients’ adiponectin also induced nitric oxide (NO), IL-6, MMP-3, MMP-9, monocyte chemoattractant protein (MCP)-1, and IL-8 and promoted inflammation by increasing TNF-α, IL-6, and IL-8 [57,67].