STAT3 and cancer: The positive effect of inhibition of JAK1,2/STAT3 signaling by curcumin has been both confirmed by in vitro studies on multiple myeloma cells [95], cancer stem cells [96], Hodgkin’s lymphoma cells [97], small lung cancer cells [98], and in in vivo models such as glioma development in a syngeneic mouse [99], a rodent model of lung cancer [100] and human non–small-cell lung cancer xenografts [101].