The relevance of studying astrocytes in the context of transgenic models of human AD is apparent in the context of the GWAS analyses, which have defined several AD-risk genes, the expression of which are enriched in astrocytes in the CNS (e.g., APOE, CLU, SERPINA1, CXCL16) [64,65]. The gene discussed is SERPINA1; the disease is Alzheimer disease.