This could be due to selective vulnerability of different brain regions to AD pathology, which is further evidenced in rTgTauEC mice, where Tau pathology is seen in brain areas with direct connection to the entorhinal cortex (the hippocampal and para-hippocampal areas, the amygdala, and the perirhinal cortex) in the absence of measurable astrogliosis (although it is present in the amygdala) [142]. This evidence concerns the gene MAPT and Alzheimer disease.