CD63 and neoplasm: Other studies have shown that CD63+/CD9+/Flotillin-1+ EVs from NPC (CNE2, CNE1, 5-8F, 6-18B) cells were enriched with a key glycolysis-regulatory enzyme, 6-Phosphofructo 2-kinase/fructose 2, 6-bisphosphatase 3, which promotes angiogenesis amongst other tumor permissive activities [36].