Furthermore, there is increasing evidence that Sco interferes with the molecular homeostasis of the extracellular signal-regulated kinase (ERK) and cAMP response element-binding (CREB)/brain-derived neurotrophic factor (BDNF) in animal models [17,18] while simulating ERK/CREB/BDNF injury in the brains of patients with AD [19,20]. Here, CREB1 is linked to Alzheimer disease.