To further increase our understanding of the contribution of the CHEK2 variant c.349A>G, which is, to date, the only recurrent “likely pathogenic” variant in CHEK2 gene reported in the Portuguese population [26], we completed the genotyping of a series of 462 cases with criteria for early-onset and/or hereditary PrCa. Here, CHEK2 is linked to pure red-cell aplasia.