A similar modest increased risk has also been reported for men harbouring pathogenic variants in other moderate-penetrance cancer genes, such as ATM [38], while a higher risk (up to 8-fold) is described for carriers of alterations in high-penetrance cancer-predisposing genes, such as those associated with hereditary breast and ovarian cancer syndrome (e.g., BRCA1 and, particularly, BRCA2) [39,40]. This evidence concerns the gene BRCA1 and Hereditary breast and ovarian cancer syndrome.