The CHEK2 gene plays a key role in DNA damage response [18], and although several germline variants have been associated with increased cancer risk, particularly in breast cancer [22,29], the mutational spectra, as observed in other cancer risk genes (e.g., BRCA1 and BRCA2 genes [30,31]), varies widely among different populations. The gene discussed is BRCA1; the disease is breast carcinoma.