ABCB1 and malignant colon neoplasm: In ABCB1-overexpressing SW620/Ad300 colon cancer cells, poziotinib also produce a concentration-dependent increase in the efficacy of paclitaxel and doxorubicin in the SW620/Ad300 but not in the SW620 parental colon cancer cells and its efficacy was greater than verapamil, an ABCB1 inhibitor [53].