After adjustment for variables with a p-value < 0.10 in the univariate analysis, eGFR (HR 0.991, 95% CI, 0.982–0.999, p = 0.048) and higher serum Gd-IgA1 (HR 1.933, 95% CI, 1.164–3.208, p = 0.011) were independent factors associated with CKD progression in IgAN patients. Here, IGHA1 is linked to chronic kidney disease.