In univariate Cos regression analysis, age (HR 1.029, 95% CI 1.012–1.046, p = 0.001), eGFR (HR 0.985, 95% CI, 0.978–0.991, p < 0.001), urine PCR (HR 1.191, 95% CI, 1.081–1.313, p < 0.001), and higher serum Gd-IgA1 (HR 2.283, 95% CI, 1.388–3.756, p = 0.01) showed a significant association with CKD progression in IgAN patients. This evidence concerns the gene IGHA1 and chronic kidney disease.