This observation was subsequently confirmed by other groups [64], and the underlying molecular mechanisms began to be unraveled; these include somatic mutations in KEAP1 [65], epigenetic hypermethylation of KEAP1 or other genes in the Nrf2 pathway [64], etc. In the present work, we review a few recent studies that have shed further light into the involvement of Nrf2 in thyroid cancer. The gene discussed is NFE2L2; the disease is thyroid gland carcinoma.