CD4 and Miyoshi myopathy: This prediction could be further improved by applying specific cut-off values; a simple MRD scoring system defined by the presence of naïve CD4+ T cells at values higher than 8% and effector/effector memory CD4+ T cells at values lower than 90% could predict MRD-positivity with a satisfactory accuracy, 86% sensitivity, and 85% specificity, when assessed in a separate MM patient cohort (Figure 6D).