Moreover, Gorzalczany et al. found that MCs-activated by cancer EVs elicited the upregulation of genes involved in tissue remodeling and angiogenesis, including VEGF, IL-8, IL-6, and amphiregulin, a ligand of Epidermal Growth Factor Receptor (EGFR) related to lung cancer progression. This evidence concerns the gene CXCL8 and cancer.