PLG and Heat Stroke: Fibrinolysis is also activated, as shown by increased levels of plasmin and d-dimers and decreased levels of plasminogen.[5] The complement system, which helps in the clearance of pathogens from organisms and plays a significant role in immune responses, is also activated in heat stroke, leading to the release of peptides, which are potent mediators of inflammatory and immune responses known as anaphylatoxins.