Furthermore, we questioned the patient's past medical history, no common symptoms, such as dry mouth or dry eyes, while the SS-related diagnoses were positive, including ANA, anti-SSA antibody, anti-SSB antibody, anti-Ro-52 antibody, Sch-I test, TBUT, and labial gland biopsy. The gene discussed is TRIM21; the disease is Keratoconjunctivitis sicca.