Now, some possible biological mechanisms for Tai chi, Qigong, acupuncture, and Tuina of breast cancer related fatigue have been suggested, such as a decrease of inflammatory cytokines,[33] an increase of T-lymphocytes[34] and beta-endorphins,[35] and improving immune function.[36] But clinical evidence-based researches of these interventions are limited. The gene discussed is POMC; the disease is breast carcinoma.