Recent studies demonstrated that loss of METTL3, METTL14, or FTO weakens acute myeloid leukemia (AML) propagation, whereas inactivation of METTL3 and METTL14 has deleterious consequences for normal HSC maintenance (Barbieri et al., 2017; Cheng et al., 2019; Li et al., 2017; Vu et al., 2017; Weng et al., 2018). This evidence concerns the gene FTO and acute myeloid leukemia.