Furthermore, inactivation of YTHDF2, which recognizes m6A-modified mRNA to mediate m6A-mRNA degradation (Du et al., 2016; Wang et al., 2015), compromises initiation and propagation of AML and results in HSC expansion (Li et al., 2018; Paris et al., 2019; Wang et al., 2018). The gene discussed is YTHDF2; the disease is acute myeloid leukemia.