Since our results show that RAC1 and ACE2 had higher co-expression in inflamed enterocytes (Fig 6I), it is highly possible that these inflamed cells are more susceptible to SARS-CoV-2 infection, and that the infection could lead to an altered RAC1 expression level through PPIs with virus target proteins STOM, HDAC2, POLA2, CIT, and RAP1GDS1 (Fig 6B). Here, HDAC2 is linked to infection.