The EMT-related mechanism of IRF6 has been demonstrated in previous studies; especially, there are many studies on the association between well-known EMT markers with IRF6: ectopic expression of IRF6 increases the expression of SNAI2 and diminishes the expression of various epithelial markers (e.g., E-cadherin) in EMT; TGFβ3 increases IRF6 expression, and IRF6 appears to regulate EMT during palatal fusion via SNAI2 [33]; IRF6 is downregulated during the EMT process of breast cancer and prostate cancer [34]. Here, TGFB3 is linked to Familial prostate cancer.