In a previous study, it was demonstrated that sterile alpha motif-pointed domain containing ETS TF (SPDEF) negatively regulates CCL2 and the EMT markers in prostate cancer cells, and the interaction between SPDEF and CDH1 (E-cadherin) related to the EMT process was also demonstrated: decreased SPDEF levels significantly induce CCL2 and CDH2 (N-cadherin), and decrease CDH1 (E-cadherin) mRNA and protein expression, confirming the association between SPDEF inhibition and EMT in cells. Here, CCL2 is linked to Familial prostate cancer.