FOXF1 and SNAI1: FOXF1 is also confirmed as an EMT-related marker, and reciprocal mechanisms of genes in this group have been demonstrated: the expression of FOXF1 inhibits cancer cell invasion and migration, whereas the inactivation of FOXF1 stimulates cell invasion and migration (Wei et al., 2014); higher level of FOXF1 is positively associated with enrichment of EMT gene signatures [19]; Overexpression of FOXF1 induces EMT by transcriptionally activating SNAI1 in colorectal cancer metastasis [19]. The gene discussed is SNAI1; the disease is colorectal cancer.