Having shown that Ryk signaling may modulate FOXO3 gene regulation through spatial/allosteric modifications of the ß‐catenin/FOXO3 complex, we used massively paralleled RNA sequencing (RNA‐seq) and chromatin immunoprecipitation followed by sequencing (ChIP‐seq) to identify FOXO3 direct targets (F3Ts) in human HD cells. Here, RYK is linked to Huntington disease.