F3T‐INs lost or gained in HD NSCs with no effect of Ryk silencing (Table S4: 214 genes) are enriched for PI3‐AKT signaling (KEGG Pathway 2016: p = 3.23 10−04) and Positive regulation of protein autoubiquitination (GOBP: p = 1.88 10−05). This evidence concerns the gene PI3 and Huntington disease.