Silencing ETS1 (Figure S6E) decreased p16INK4a mRNA levels in HD and C116 NSCs under basal conditions, an effect that was lost upon growth factor deprivation in C116 NSCs, but not HD NSCs (Figure 3d), suggesting that ETS1 remains able to promote p16INK4a expression in HD NSCs under stressed conditions. Here, CDKN2A is linked to Huntington disease.