Nonetheless, in HD cells, our data suggest that pathways that signal onto FOXO3 such as Ryk/Ryk‐ICD signaling play a primary role in modifying the F3T repertoire, rendering FOXO3 able to fine‐tune the expression of key inducers of cellular senescence such as p16INK4a, whereas the increase of FOXO3 occupancy may primarily reflect the wide‐spread effect of HD on chromatin remodeling (Achour et al., 2015). This evidence concerns the gene RYK and Huntington disease.